Hello, I’m Jin Pharmacist. : D Let’s take a look at calcium channel blockers, the third medicine for high blood pressure.
ACTION MECHANISM AND USE OF CALCIUM CHANNEL BLOCKER
ACTION MECHANISM AND USE OF CALCIUM CHANNEL BLOCKER
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Types of calcium channels and sources of blocking agents acting on them_Currhypertens Rev. 2006 May 1;2(2):103-111
calcium channel breaker may vary depending on drugs and heart muscles, depending on drugs, and heart muscles may vary depending on drugs.calcium channel blocking agent reduces blood pressure, but the heart failure may deteriorate in progress in the heart contraction action, the cardiac contraction effect in the heart contraction effect.In the other hand, the case of a spasm) can be treated with a calcium channel block agent or organic nitric acid salt.(usually narrow heart disease) is different from “usually small, and blood vessels, and blood vessels are likely to be reduced in stability and the blood vessels) and the electrocardiogram
Calcium channel blockers may have different indications due to different affinity between blood vessels and heart muscles.Calcium channel blockers reduce blood pressure, but in the case of cardiac selective calcium channel blockers, heart contraction inhibitors can worsen ongoing heart failure, which weakens myocardial contraction.On the other hand, for atypical angina caused by contraction of coronary arteries due to spasm, calcium channel blockers or organic nitrates can be used to treat them.(Unlike “common angina caused by chronic cholesterol or blood clots deposited in blood vessels and narrowing of blood vessels,” heteromorphic angina can also appear when stabilized, raising the ST segment of the electrocardiogram.) Type and classification
Source of advantages and disadvantages of calcium channel blockers according to action time and receptor type_Currhypertens Rev. 2006 May 1;2(2):103-111
The first generation drug is a quick effect (trap) and short duration of the pain in the mechanism that has no impact on the cause of the pain in the heart failure.The second generation of drugs can reduce the risk of reaction (onset) and long-term sustainability of reaction (reongset) and reduce the risk of reaction.You can also take action (phenotrop Office Protection) can also be taken.p.motropolic blood vessels, including nitrogen dioxide and the oxidative effect of the blood vessel, including the abnormal growth of the blood vessel, and the internal cell-cellular cell.
Comparative source of calcium channel blockers by generation 1-4_Journal of Geriatric Cardiology 2017 14:67-72
CCB (T-type and N-type channel agonists in addition to L-type channels) with kidney protection functions
afferent and centrifugal arterioles source_wikipedia
In the kidney, the blood is moved to the center of the heart of the heart of the heart of the center (a spherical body)→ centrifugal artery (a)→ centrifugal artery (a).ANTIUM channel is superior to the L-type calcium channel is superior to the centrifugal type of calcium channel, and the calcium-type-type fiber-type, and the calcium channel is also operated by a constant,アンジオテンシン2受容体遮断剤(ARB)ほどの蛋白尿減少を示し、腎臓保護機能を示します.
Comparative source_source_Currhypertens Rev for afferent and efferent arteriolar relaxation effects. 2006 May 1;2(2):103-111
efonidipine shows L-type and T-type calcium channel blocking effect, and cilnidipine shows L-type and N-type calcium channel blocking effect. Studies have shown that drugs that act on T and N-type calcium channels as well as L-type have less reactionary sympathetic stimulation due to vasodilation.(Blood pressure 2012 Jul 03:367-371) ◆ Various effects of cilnidipine4th Generation Calcium Channel Blocker Cilnidipine Action Mechanism Source_Indian heart journal 652013691-695① It has the effect of vasodilating, 心臓 relaxing cardiac smooth muscle, reducing heart rate, 腎 increasing renal blood flow and normalizing renin secretion. a variety of effectsVasc Biol is an arteriosclerotic thrombus. US>2003 Month 2155-2163① It mainly works on L-type calcium channels, blocks calcium inflow into smooth muscle cells, and has vasodilating effect through smooth muscle relaxation. Some calcium channel blockers also affect cells that are less affected by L-type calcium channels other than vascular smooth muscle (VSMC).Vasc Biol is an arteriosclerotic thrombus. US>2003 Month 2155-2163② In the presence of calcium channel blockers (CCBs), proton-donating and resonance-stabilization mechanisms inhibit free radical propagation to phospholipid double membranes.Vasc Biol is an arteriosclerotic thrombus. US>2003 Month 2155-2163③ When the R+ isomer of amlodipine is in the cell membrane, nitrogen oxide (NO) production reaction that relaxes blood vessels is promoted.Vasc Biol is an arteriosclerotic thrombus. US>2003 Month 2155-2163④ DHP calcium channel blockers have potential effects. It can control the proliferation and growth of vascular smooth muscle cells and reduce the risk of developing Takegami arteriosclerosis by acting on lipid oxidation and cholesterol metabolism.It is predicted to be a mechanism that upwardly modifies the expression of interleukin, which has an anti-proliferative effect, and shows favorable effects on remodeling of extracellular substrates. It’s using Amlodipine amlodipineOn the above, the two generation of calcium channels, such as the default ip line, the kidney failure of the patient with a kidney failure, and the kidney functionality of the patient with the kidney function.Compared to the third generation of the third generation, thea mls ip line is better, and the benefits of the patient with a long time, and the long time of the long time.The recent study, theamod ip line has also been known as L-type calcium receptor block action.(N, such as N, bls modip line, bilnid ip line, barnid ip line, nid ip line, barnid ip line, barnidip line, barL, N, P/Q, R 슘칼 적인) November 29, 1999 (2) 464-473. Journal of Pharmacy and Experimental Therapy by Yasuharu FURUKAWA, Takeshi YAMAGAWA, Takayuki GOTERA, Toshio SAGAWA, Yasuo MORI, Toshihide Noda;In a comparative experiment with cilnidipine, amlodipine showed other benefits besides reducing blood pressure (although the clinical data of cilnidipine is relatively small).It is beneficial for pedaledema at the end of the lower extremity, has a proven benefit of cardiovascular risk (CVoutcome), helps reduce stroke, reduces the progression of chronic kidney disease (CKD), reduces proteinuria and has low drug prices.(See table below)Amlodipine is a new generation calcium channel blocker. Tiwaskar, A. Langote, R. Kashyap, A. Tteokbokki Announces 2018 Medicine Journal of the Indian Medical Associationa side effect.a side effect.Ref. arteriosclerotic thrombus Vasc Biol. December 2003 2155-2163, Amlodipine during the New Generation Calcium Channel Blockers era. Tiwaskar, A. Langote, R. Kashyap, A. Topo, Curr hypertens Rev. May 1, 2006; 2(2): 103-111, Journal of Geniatric Cardiology 2017 14:67-72